Neuropathy is a term used in describing a nerve problem, usually affecting the peripheral nerve. Neuropathy is experienced with different medical conditions which are considered the underlying factors. Sometimes the condition can exist without a known cause and in this case, it is referred to as idiopathic. There are different medical conditions known to cause neuropathy including diabetes,cancers, poisons or toxins, chronic kidney disease, connective tissue diseases among many others. Neuropathic pain can reduce the patient’s quality of life and render them unable to handle their daily activities. This is why this condition should be treated when the symptoms are identified.
There are a number of treatment methods used in the management of neuropathy by different doctors. Whether it is a single or multiple nerves affected by neuropathy, the treatment is mostly geared towards the underlying medical condition. When there is no underlying medical condition or the condition is irreversible, then the treatment takes the direction of sympathetic pain relief. Some of the treatment approaches include drug treatment, complementary therapies and other non-drug treatments. Stem cell has now been identified as an effective treatment method when it comes to the management of neuropathy.
Stem cells are the undifferentiated biological cells which can differentiate into specialized cells and then divided through mitosis to create more stem cells. The stem cells are found in multicellular organisms, and in mammals, there are different types of these cells. Stem cells are used in the body to assist in regenerative organs such as the skin, blood, intestinal tissues and blood. There are three known ways to access stem cells and these include the bone marrow, blood and adipose tissue. The umbilical cord blood after birth is another source for stem cells. Of all the procedures used in the acquiring of stem cells, the autologous procedure is the least risky. This is because the procedure involves taking the stem cells from one’s body and can be likened to banking one’s blood during surgical procedures.
Adult stem cells are now used in medical therapies such as bone marrow transplant. The cells can be grown artificially and differentiated to specialized cells in different body tissues such as the nerves and muscles and this is how stem cell can be used in the management of neuropathy.
Because stem cells have an unlimited self renewal ability and proliferation, they are used in treatments and therapies for different medical conditions. Stem cells exist in three main types which are embryonic stem cells, adult stem cells and induced pluripotent stem cells. Let us look at each of these stem cells and their effectiveness in the treatment of neuropathy.
Embryonic cells are just pluripotent cells that have been taken from the inner cell mass blastocyst in development. These cells have a major advantage because they are highly renewable and access genetic modification. They also have a benefit of being expandable in vitro for long periods. These cells can therefore be yielded in high pure quantities for regenerative procedures. The disadvantages of embryonic stem cells include the high tumorigenic risk, rejection in transplant and the ethical issues surrounding the blastocyst development.
These are multipotent undifferentiated cell taken from specific tissues in an adult, foetus and embryo such as the bone marrow which carries two adult stem cell types, the haematopoeitic stem cells and MSCs. The amniotic membrane is also found to contain a large quantity of the easy to harvest non-immunogenic MSCs. These particular stem cells have been reported to have anti-inflammatory properties which are useful in enhancing healing of wounds and pain relief.
The advantage of the adult stem cells when used in treatment is that they have self-renewability properties, fewer ethical issues as compared to the embryonic stem cells and they can be easily harvested from organs that are easily accessible which means the process is less invasive. These cells have a safety level that is better than the ES cells. The disadvantage includes a low plasticity degree, and the invasive harvest method such as biopsy and bone marrow trephine. In mature cells, the adult stem cells are quite rare and this means that there will be a large number needed for successful stem cell replacement therapies.
The induced pluripotent stem cells are taken from non-pluripotent somatic cells like dermal fibroblasts. There are traditional strategies used in the reprogramming of somatic cells to the state of iPS. These are nuclear transfer, cell fusion, viral transduction and cell explantation. The reprogramming is usually achieved through viral vectors which can be integrating such as lentiviral vectors or retroviral vector or non-integrating like adenoviral vectors.
The iPS cells have an advantage of being harvested since the procedure is non-invasive and can be useful in the development of drugs. These cells have a lower immunorejection risk and thus can be used in transplantation. The main disadvantage is the lack of data on safety and stability.
Get Neuropathy Treatment At Integrated Pain Management Clinic It you are suffering from neuropathy or neuropathic pain, you are probably in agony and would like to get out of the situation as soon as possible. It is important that you consult a doctor who understands the different methods that are used in treating this condition. You can choose any of the available methods which will ensure that your get your life back through pain relief. At Integrated Pain management, we believe in solving pain issues to improve the quality of live of our patients. If your daily life activities have been affected by neuropathy, you can talk to our doctors and your condition will be treated through the available neuropathy treatment methods including stem cell. We are professional medical experts, trained and experienced in dealing with multiple pain conditions and will ensure that your condition improves and you get back to your normal life free of pain and discomfort that comes with pain.